Reciprocal Intraepithelial Interactions Between TP63 and Hedgehog Signaling Regulate Quiescence and Activation of Progenitor Elaboration by Mammary Stem Cells
نویسندگان
چکیده
منابع مشابه
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells.
The epithelial components of the mammary gland are thought to arise from stem cells with a capacity for self-renewal and multilineage differentiation. Furthermore, these cells and/or their immediate progeny may be targets for transformation. We have used both in vitro cultivation and a xenograft mouse model to examine the role of hedgehog signaling and Bmi-1 in regulating self-renewal of normal...
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Regulation of Mammary Stem/Progenitor Cells by PTEN/Akt/β-Catenin Signaling
Recent evidence suggests that many malignancies, including breast cancer, are driven by a cellular subcomponent that displays stem cell-like properties. The protein phosphatase and tensin homolog (PTEN) is inactivated in a wide range of human cancers, an alteration that is associated with a poor prognosis. Because PTEN has been reported to play a role in the maintenance of embryonic and tissue-...
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ژورنال
عنوان ژورنال: Stem Cells
سال: 2008
ISSN: 1066-5099,1549-4918
DOI: 10.1634/stemcells.2007-0691